Completed all levels on Normal
Obtained all Alternate Suits
Obtained all Newspapers
Completed Act 3 on any difficulty level
Defeated the CEO on any difficulty level
Defeated Atrocity on any difficulty level
Obtained all Golden Spiders
Web of Challenges - Obtained all Gold Medals
Teleported back to Alchemax with the Key
Brought the Incinerator to Maximum Power
Bought all Combat Upgrades
Bought all Character Upgrades
Retrieved all three DNA Samples from the knocked-out Atrocity
Analyzed all Data Modules
Executed a 200-hit combo
Performed 3 of each Air Attack on enemies
Performed 3 of each type of Grab Attacks on enemies
Completed Act 2 on any difficulty level
Defeated Black Cat on any difficulty level
Gained access to the Restricted Archives Computer
Completed Session 3 or later without dying
Collected 2000 Orb Fragments
Collected all three Atomic Fuses
Web of Challenges - Obtained all Gold Medals for an Act
Damaged enemies with Roundhouse Spin and Web Hammer 10 times each
Defeated 500 enemies
Collected 1000 Orb Fragments
Stopped the future from becoming a radioactive wasteland
Floor 66 Reached
Executed a 100-hit combo
Avoided 100 attacks with Accelerated Decoy
Evaded 100 attacks with Hyper-Sense
Completed a Freefall section by boosting the entire time
Erased the Prototype Combat Robot from existence
Defeated 100 enemies
Collected 500 Orb Fragments
Web of Challenges - Obtained all Gold Medals for a Chapter
Foreseen the death of Spider-Man
Executed a 50-hit combo
Spider-Man was down and out
Completed Act 1 on any difficulty level
Completed all levels on Hard
Defeated Anti-Venom on any difficulty level
Gained access to the Future Restricted Area
Saved Mary Jane
Obtained 1/4 of the Golden Spiders
Obtained 1/2 of the Golden Spiders