The player has completed the game without harvesting any Little Sisters.
The player has either Harvested or Rescued every possible Little Sister
The player has acquired all upgrades for all weapons.
The player has fully upgraded five weapons.
The player has successfully invented all possible ammo types.
The player has entered Sander Cohen's personal quarters.
The player has maxed out all possible research.
The player has fully researched the Bouncer.
The player has taken a picture of Sander Cohen's corpse
The player has defeated Atlas
The player has fully researched the Little Sister.
The player has become a Big Daddy.
The player has successfully completed 50 hacks.
The player has purchased every slot in all four Plasmid and Tonic tracks
The player has fully upgraded four weapons.
The player has broken Fontaine's mind control
The player has fully researched the Rosie.
The player has fully researched the Nitro Splicer.
The player has defeated Andrew Ryan
The player has fully researched the Houdini Splicer.
The player has fully upgraded three weapons.
The player has purchased every slot in one of the Plasmid or Tonic tracks
The player has completed Sander Cohen's great masterpiece
The player has fully researched the Thuggish Splicer.
The player has fully researched the Spider Splicer.
The player has taken at least one photo in every research group.
The player has fully upgraded two weapons.
The player has restored the forests of Arcadia
The player has fully upgraded one weapon.
The player has successfully hacked a security camera.
The player has fully researched the Leadhead Splicer.
The player has successfully invented at least one item.
The player has successfully hacked a turret.
The player has acquired at least one weapon upgrade.
The player has defeated Peach Wilkins
The player has taken at least one Research Photo of a Splicer.
The player has taken a Research Photo of the highest grade.
The player has successfully hacked a vending machine.
The player has purchased one slot in any Plasmid or Tonic track
The player has defeated the crazed Dr. Steinman
The player has successfully hacked a safe.
The player has successfully hacked a security bot.
The player has performed at least one successful hack.
The player has successfully completed the Welcome To Rapture Level.
The player has shocked an enemy in the water.
The player has successfully invented at least 100 items.
The player has collected or invented 53 Tonics in the Physical, Engineering and Combat tracks
The player has found every audio diary.
The player has completed the game on the hardest difficulty setting.
The player has hit the jackpot at a slot machine
Complete the game on Hard difficulty without using a Vita-Chamber
