Cure 1 Patient
Knock the socks off of Bartholomew F. Yeti
Conduct 25 Machine Upgrades
Run 50 Marketing Campaigns
Complete 50 Research Projects
Train a World-Class Surgeon
Train a World-Class Psychiatrist
Complete 50 Research Nodes
Complete Superbug Project "Hair Removal"
Complete a Multiplayer Challenge
Unlock every plot in Overgrowth
Train a World-Class Researcher
Complete Wave 42 on Topless Mountain
Earn 1 Star at each hospital on Pebberley Island
Earn 63 Gold Stars
Get a Curing Spree on Topless Mountain
Have a Level 5 De-lux Clinic at the Underlook Hotel
Earn 15 Gold Stars
Complete the "Cheesier Gubbins" Research Project in Swelbard
Earn 54 Gold Stars
Earn 1 Star at each hospital in the Pointy Mountains
Injure someone with an exploding machine
Cure 1000 Patients
Shoot 10 Monobeasts in a row without missing
Shoot 1 Monobeast
Win every award in a single hospital
Have a Level 20 Hospital
Have a Level 10 Hospital
Earn 10,000 Kudosh
Reach $50,000,000 Organisation Value
Earn 45 Gold Stars
Earn 30 Gold Stars
Capture 100 Ghosts