Reach Level 50 (Multiplayer Only).
Beat up the 5 thirsty harlequins.
Remove All Borgia Flags in Rome.
Receive 100% synch in ACB and full synch in all missions of the Da Vinci Disappearance.
Complete the Da Vinci Disappearance.
Kill 10 guards with a single arrow storm.
Win 10000 florins playing Hazard.
Double Assassinate from a parachute.
Get every single bonus at least once (Multiplayer Only).
Steal 5 horses from their riders, while remaining on horseback.
Kill a guard with the bag that drops from a lift.
Throw a Long Weapon, Heavy Weapon, and Smoke bomb more than 10 m at a guard.
Pay 500 florins to an orator, then pickpocket him afterward.
Take the lead 10 seconds before the end of a session and go on to win (Multiplayer Only).
Get all the Co-op bonuses in 1 session (Multiplayer Only).
Kill your target while hidden in a hay bale (Multiplayer Only).
Score 750 points or more on a single kill (Multiplayer Only).
Perform a double or triple escape (Multiplayer Only).
Kill your target and escape your pursuer in less than 10 seconds (Multiplayer Only).
During Open Conflict, kill your target and escape (Multiplayer Only).
Complete an entire Session with at least one kill (Multiplayer Only).
Secure the Apple of Eden.
Complete DNA Sequence 9.
Complete DNA Sequence 8.
Discover the Shrine in the Basilica di San Pietro.
Jump with the parachute off the top of Castel Sant'Angelo.
Solve all of Subject 16's puzzles.
Complete DNA Sequence 7.
Discover the Shrine in Palazzo Laterano.
Burn All Borgia Towers.
Discover the Shrine in the Cloaca Maxima.
Complete DNA Sequence 6.
Collect All Feathers.
Destroy the Tank.
Complete DNA Sequence 5.
Destroy the Bomber.
Destroy the Naval Cannon.
Train a recruit up to the Rank of Assassin.
Win the highest bet at the Fights.
Complete DNA Sequence 4.
Destroy the Machine Gun.
Recruit 3 Assassins.
Complete 10 Guild Challenges.
Complete DNA Sequence 3.
Achieve 100% Synchronization in any Sequence other than Sequence 1.
Earn 3 gold medals in the Animus Virtual Training Program.
Perform an Execution Streak of 10 kills.
Discover the Shrine in the Catacombe di Roma.
Find 1 Artifact in 2012.
Renovate 5 buildings in the Antico district.
Discover the Shrine in Il Colosseo.
Complete DNA Sequence 2.
Discover the Shrine in the Terme di Traiano.
Replay a Memory.
Access your email in 2012.
Kill a guard with a broom.
Throw money in a well.
Find a secure place to hide and re-enter the Animus.
Complete DNA Sequence 1.
Attempt to access DNA Sequence 9 for the first time.