Complete an entire Session with at least one kill (Multiplayer Only).
Solve all of Subject 16’s puzzles.
Replay a Memory.
Destroy the Tank.
Throw money in a well.
Destroy the Naval Cannon.
Secure the Apple of Eden.
Achieve 100% Synchronization in any Sequence other than Sequence 1.
Complete DNA Sequence 9.
Complete DNA Sequence 8.
Win the highest bet at the Fights.
Discover the Shrine in the Basilica di San Pietro.
Kill a guard with a broom.
Complete DNA Sequence 7.
Collect All Feathers.
Discover the Shrine in the Cloaca Maxima.
Discover the Shrine in Palazzo Laterano.
Discover the Shrine in Il Colosseo.
Complete 10 Guild Challenges.
Perform an Execution Streak of 10 kills.
Earn 3 gold medals in the Animus Virtual Training Program.
Burn All Borgia Towers.
Complete DNA Sequence 6.
Train a recruit up to the Rank of Assassin.
Complete DNA Sequence 5.
Destroy the Bomber.
Complete DNA Sequence 4.
Destroy the Machine Gun.
Recruit 3 Assassins.
Complete DNA Sequence 3.
Discover the Shrine in the Catacombe di Roma.
Renovate 5 buildings in the Antico district.
Access your email in 2012.
Complete DNA Sequence 2.
Discover the Shrine in the Terme di Traiano.
Find a secure place to hide and re-enter the Animus.
Complete DNA Sequence 1.
Attempt to access DNA Sequence 9 for the first time.
Win every trophy.
Remove All Borgia Flags in Rome.
Find 1 Artifact in 2012.
Jump with the parachute off the top of Castel Sant'Angelo.
Kill your target while hidden in a hay bale (Multiplayer Only).
Take the lead 10 seconds before the end of a session and go on to win (Multiplayer Only).
Kill your target and escape your pursuer in less than 10 seconds (Multiplayer Only).
During Open Conflict, kill your target and escape (Multiplayer Only).
Reach Level 50 (Multiplayer Only).
Get all the Co-op bonuses in 1 session (Multiplayer Only).
Score 750 points or more on a single kill (Multiplayer Only).
Get every single bonus at least once (Multiplayer Only).
Perform a double or triple escape (Multiplayer Only).
Throw a Long Weapon, Heavy Weapon, and Smoke bomb more than 10 m at a guard.
Win 10000 florins playing Hazard.
Receive 100% synch in ACB and full synch in all missions of the Da Vinci Disappearance.
Kill 10 guards with a single arrow storm.
Complete the Da Vinci Disappearance.
Beat up the 5 thirsty harlequins.
Double Assassinate from a parachute.
Steal 5 horses from their riders, while remaining on horseback.
Kill a guard with the bag that drops from a lift.
Pay 500 florins to an orator, then pickpocket him afterward.