Unlock all snake masks
Perform a 15x combo
They won't reach the Nuclear Throne
Destroy 100 electronic devices
Die 1000 times
Unlock all the Fans
Finish HOMICIDE without using guns
Clear the 1st floor of NO MERCY with the silencer
Perform a 10x combo
Perform a 5x combo
Do as the Director says!
Unlock all Trophies
Finish the game
Finish the game on hard mode
Get A+ on all levels on normal
Unlock all weapons for the Soldier
Unlock all of the Son's techniques
Clear a level with each Fan
Clear a level with each of the Son's techniques
Clear a level with each snake mask
Clear all of the Writer's levels without killing
Get the big picture
Use every weapon in the game at least once
Kill 50,000 enemies
Shoot two enemies during a chainsaw finish
Finish SUBWAY without the Gang Leader seeing you
Unlock THE ABYSS
Meet up with the Biker
Perform a 20x combo