Earn all trophies.
Obtain all weapons.
Finish the game without saving.
Finish the game with rank S.
Finish the game on Hard difficulty.
Defeat Mimicry Marcus for the first time only using a knife.
Defeat an enemy with a knife.
Put on Team Wesker costume.
Destroy a zombie's legs.
Defeat 16 bats in the church.
Use a Green Chemical.
Kill 50 enemies with the Death Stare at full charge.
Collect all of only one color of Leech Charms.
Defeat all bosses except Centurion using Rebecca.
Finish the game without using a recovery item (including Green Chemicals).
Finish the game without combining herbs.
Finish the game without using a First-Aid Spray.
Read all files.
Defeat Mimicry Marcus with a Molotov Cocktail or a Napalm Grenade.
Get picked up by the Infected Bat.
Play the piano using Rebecca.
Finish Leech Hunter with rank A.
Finish Leech Hunter with rank E or above.
Defeat all enemies in Leech Hunter.
Shoot down a Hunter or an Eliminator while they are jump attacking in the air.
Play Leech Hunter.
Combine every type of herb with each other.
Complete the treatment plant.
Defeat Queen Leech.
Obtain all keys and use them all.
Defeat the Proto Tyrant.
Complete the factory.
Fight off the Proto Tyrant.
Complete the laboratory.
Defeat Infected Bat.
Defeat an enemy by burning them.
Complete the training facility.
Create a Molotov Cocktail.
Create a Custom Handgun.
Defeat a zombie by stomping on them.
Try to push something heavy with Rebecca.
Change into a costume.
Defeat Centurion.
Attack an enemy to save your partner who is grappling with that enemy.
Complete the train.
Defeat Stinger.
Defeat an enemy with a critical-hit headshot.
Break free of a Cerberus while they are biting you or trying to push you down.