Finish Leech Hunter with rank E or above.
Play Leech Hunter.
Complete the treatment plant.
Finish the game without using a First-Aid Spray.
Defeat Queen Leech.
Read all files.
Obtain all keys and use them all.
Defeat the Proto Tyrant.
Complete the factory.
Fight off the Proto Tyrant.
Complete the laboratory.
Destroy a zombie's legs.
Defeat Infected Bat.
Get picked up by the Infected Bat.
Complete the training facility.
Create a Custom Handgun.
Use a Green Chemical.
Shoot down a Hunter or an Eliminator while they are jump attacking in the air.
Play the piano using Rebecca.
Defeat Mimicry Marcus with a Molotov Cocktail or a Napalm Grenade.
Defeat a zombie by stomping on them.
Try to push something heavy with Rebecca.
Defeat Centurion.
Defeat an enemy with a critical-hit headshot.
Complete the train.
Defeat an enemy with a knife.
Attack an enemy to save your partner who is grappling with that enemy.
Defeat an enemy by burning them.
Create a Molotov Cocktail.
Defeat Stinger.
Change into a costume.
Break free of a Cerberus while they are biting you or trying to push you down.
Earn all trophies.
Finish the game with rank S.
Finish the game on Hard difficulty.
Finish the game without combining herbs.
Finish the game without saving.
Finish the game without using a recovery item (including Green Chemicals).
Defeat all bosses except Centurion using Rebecca.
Defeat Mimicry Marcus for the first time only using a knife.
Combine every type of herb with each other.
Obtain all weapons.
Defeat 16 bats in the church.
Put on Team Wesker costume.
Finish Leech Hunter with rank A.
Collect all of only one color of Leech Charms.
Defeat all enemies in Leech Hunter.
Kill 50 enemies with the Death Stare at full charge.