Beat the top score on the "Life Support Room" Challenge
Survive the shuttle flight with less than 10% shields intact
Beat the top score on the "Atrium" Challenge
Beat the top score on the "Shuttle Bay 47" Challenge
Beat the top score on the "East Grow Chamber" Challenge
Beat the top score on the "Mess Hall" Challenge
Beat the top score on the "Maintenance Bay" Challenge
Beat the top score on the "Water Tunnels" Challenge
Beat the top score on the "Medical Bay" Challenge
Beat the top score on the "Central Plaza" Challenge
Beat the top score on the "Extraction Site" Challenge
Collect all weapons, text logs and audio logs on Chapter 3: "Return to the Megavents"
Complete the game on "Impossible"
Complete the game on "Expert"
Complete the game on "Hard"
Collect all weapons, text logs and audio logs on Chapter 9: "Escaping the Ishimura"
Collect all weapons, text logs and audio logs on Chapter 5: "Emergency Care"
Admire the view in the crashed shuttle
Complete any level with at least 80% Perfect Reloads
Collect all weapons, text logs and audio logs on Chapter 1: "Worlds Apart"
Open the secret weapons store in P-Sec
Shoot the box hanging from the crane on the surface of Aegis 7
Complete any level with a 5 star rating
Complete the game on "Normal"
Complete Chapter 10: "Secrets and Salvation"
Complete Chapter 9: "Escaping the Ishimura"
Defeat the giant necromorph on the hull of the Ishimura
Play cooperatively with a second player
Earn 30 stars on one profile
Complete any level with at least 80% Weapon Accuracy
Complete Chapter 8: "In the Hearts of Men"
Complete any level with at least 80% Stasis Accuracy
Complete Chapter 7: "Life and Death"
Defeat the Brute
Collect every weapon on one profile
Complete Chapter 6: "Nowhere to Hide"
Defeat the giant necromorph in the water tunnels
Complete Chapter 5: "Emergency Care"
Complete Chapter 4: "Rendezvous with Fate"
Earn 10 stars on one profile
Complete Chapter 3: "Return to the Megavents"
Take a minor detour in the megavents
Complete Chapter 2: "Another Day at the Office"
Complete Chapter 1: "Worlds Apart"
Unlock all trophies
Earn 50 stars on one profile
Collect all weapons, text logs and audio logs on Chapter 8: "In The Hearts of Men"
Max out all upgrades for every weapon on one profile
