Acquire all trophies.
Max out your Trust Level.
Max out your Empathy Level.
Max out your Synergy Level.
Max out your Insight Level.
Max out your Toxicity Level.
Acquire every Toxicant, Antidote, and Catalyst.
Upgrade 10 total Toxicants, Antidotes, or Catalysts to Rank 5.
Complete the game with any Normal Ending.
Complete the game with the Yomi Sake Bottle Ending.
Acquire every Deliriant at least once.
Defeat Hakugin.
Purchase the Yomi Sake Bottle.
Reach the Fifth Circle of Hell.
Defeat White Poisonette
Clear all Belles' Hells.
Reach Level 50.
Defeat Black Poisonette
Reach the Fourth Circle of Hell.
Upgrade one poison to Rank 5.
Reach Level 30.
Reach the Third Circle of Hell.
Defeat 1,000 Kleshas
Defeat 500 Kleshas
Unlock a Toxicant slot by reaching Insight Level 3.
Reach the Second Circle of Hell.
Unlock a skill by upgrading a poison.
Reach Level 10.
Upgrade any poison to Rank 2.
Defeat 100 Kleshas
Unlock a skill during a Heart-to-Heart.
Purify your first Belle's Hell.
Have your first Heart-to-Heart.
Acquire a poison by collecting three poison gems for the first time.
Speak to your first thoughtform.