Earn all trophies.
Finish the game on Hard difficulty.
Obtain all weapons.
Finish the game with rank S.
Finish the game without using a recovery item (including Green Chemicals).
Finish the game without using a First-Aid Spray.
Finish the game without combining herbs.
Finish the game without saving.
Collect all of only one color of Leech Charms.
Finish Leech Hunter with rank A.
Defeat all enemies in Leech Hunter.
Put on Team Wesker costume.
Kill 50 enemies with the Death Stare at full charge.
Finish Leech Hunter with rank E or above.
Play Leech Hunter.
Defeat Queen Leech.
Defeat all bosses except Centurion using Rebecca.
Complete the treatment plant.
Read all files.
Obtain all keys and use them all.
Defeat the Proto Tyrant.
Complete the factory.
Fight off the Proto Tyrant.
Complete the laboratory.
Combine every type of herb with each other.
Defeat 16 bats in the church.
Use a Green Chemical.
Defeat Infected Bat.
Try to push something heavy with Rebecca.
Defeat Mimicry Marcus for the first time only using a knife.
Destroy a zombie's legs.
Defeat an enemy with a knife.
Change into a costume.
Break free of a Cerberus while they are biting you or trying to push you down.
Get picked up by the Infected Bat.
Complete the training facility.
Play the piano using Rebecca.
Shoot down a Hunter or an Eliminator while they are jump attacking in the air.
Create a Custom Handgun.
Defeat a zombie by stomping on them.
Defeat Centurion.
Defeat an enemy by burning them.
Defeat Mimicry Marcus with a Molotov Cocktail or a Napalm Grenade.
Complete the train.
Create a Molotov Cocktail.
Defeat an enemy with a critical-hit headshot.
Attack an enemy to save your partner who is grappling with that enemy.
Defeat Stinger.
