Complete Not a Hero on Easy or Normal difficulty.
Complete the game on Easy.
Complete the game on Normal.
Kill an enemy by attaching a Remote Bomb to them and detonating it.
Watch all the videotapes in a single playthrough.
Create all items that contain Chem Fluid and Strong Chem Fluid.
Take down two or more enemies with one shot.
Complete the "Happy Birthday" videotape within 5 minutes.
Clear insects off a door using a knife.
Increase your item slots.
Use a lock pick to open something.
Finish off an enemy with the knife.
Use psychostimulants.
Complete the "Mia" videotape without being spotted by Marguerite.
Put an unrelated object on a shadow plinth.
Obtain something by closely examining an item.
Destroy a Mr. Everywhere statuette.
Block an enemy attack by guarding.
Close an open door by yourself.
Complete the game on Madhouse.
Obtain all of the Antique Coins in Easy or Normal difficulty.
Obtain all of the Antique Coins in Madhouse difficulty.
Read all of the files in a single playthrough.
Destroy all Mr. Everywhere statuettes.
Complete the game within 4 hours.
Complete the game without opening the Item Box more than 3 times.
Complete the game using only 3 First Aid Meds or less.
Complete Nightmare.
Complete Night Terror.
Complete Bedroom.
Find all the dead rats in Bedroom in a single play.
Complete Ethan Must Die.
Complete 21.
Complete Survival mode in 21.
Complete Survival+ mode in 21.
Get the bad ending in Daughters.
Get the true ending in Daughters.
Clear a stage with a 10 minute time bonus or higher in Jack's 55th Birthday.
Feed Jack every type of food and drink in Jack's 55th Birthday.
Get an S Rank or higher on all stages in Jack's 55th Birthday.
Complete End of Zoe on Easy or Normal.
Complete End of Zoe on Normal or Joe Must Die using no weapons.
Complete an Extreme Challenge in End of Zoe.
Perform a 4-hit combo with your bare fists in End of Zoe.
Stealth kill 5 enemies in End of Zoe.
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