Equip your first Relic item.
Complete 5 Priority Assignments.
Kill 5000 enemies with melee skills.
Open 100 supply chests.
Reach Inquisitorial Rank 20 with at least one character.
Complete 10 Investigations on the highest difficulty.
Kill 2500 Horde type enemies.
Deal with 50 traps.
Kill 5000 enemies with ranged skills.
Kill 50 Commander enemies.
Complete 25 missions without dying.
Complete at least one mission from every type on the StarMap.
Kill 250 Champion enemies.
Get "Unbreakable" bonus 30 times.
Achieve "Killstreak" bonus 30 times.
Kill 50 enemies while they are in cover.
Achieve "Massacre" bonus for the first time.
Complete 25 side events during the missions.
Unlock the "Agartha" Subsector.
Reach 1500 Score in City of Suffering (DLC required).
Destroy 100 Pain Catalysts in City of Suffering (DLC required).
Kill 1000 Dark Eldar enemies.
You have eradicated the Coterie of Dissonance from the Triglav Subsector.
Kill 1000 Khorne enemies.
Kill 2500 Enemies by your Kastelan Robots (Tech-Adept only).
Kill 20 Elite enemies on your level or higher (Tech-Adept only).
Complete a mission dealing damage only by your Construct turrets on your level or higher (Tech-Adept only).
Kill 1000 enemies with grenade.
Complete 5 missions without taking any Melee damage (Tech-Adept only).
Summon 1000 Constructs (Tech-Adept only).
Complete 25 missions without losing a single Construct (Tech-Adept only).
Craft 25 items.
Complete a Priority Assignment on Impossible difficulty or higher.
Revive each other 50 times.
Complete an entire Priority Assignment sequence without dying.
Complete a mission in local coop.
Complete 10 Void Crusade missions.
Join a Cabal.
Complete 10 Cabal directives with your Cabal.
Complete 50 multiplayer missions.
Kill 100 Elite creatures.
Blow up 250 explosive containers.
Use Booster type Inoculator component 250 times.
Get "Angel of Death" bonus 30 times.
Fuse a socket into a Relic item.
Acquire 5000 Fate points.
Learn all the skills from a single Skill tree.
Unlock all Skill trees.
Research 10 Tech tree upgrades.
Reach Inquisitorial Rank 50 and complete a mission in a Warzone.
Reach maximum points in a Weekly Glory challenge.
Create 100 Warp anomalies (Psyker only).
Execute 50 enemies (only with Assassin or Crusader).
Kill 5 Boss creatures.
Earn all Trophies to please the Emperor of Mankind.