Complete 25 missions without dying.
Kill 250 Champion enemies.
Achieve "Killstreak" bonus 30 times.
Equip your first Relic item.
Achieve "Massacre" bonus for the first time.
Destroy 100 Pain Catalysts in City of Suffering (DLC required).
Kill 50 enemies while they are in cover.
Kill 1000 Dark Eldar enemies.
You have eradicated the Coterie of Dissonance from the Triglav Subsector.
Unlock the "Agartha" Subsector.
Kill 5 Boss creatures.
Reach 1500 Score in City of Suffering (DLC required).
Complete 25 missions without losing a single Construct (Tech-Adept only).
Kill 5000 enemies with ranged skills.
Summon 1000 Constructs (Tech-Adept only).
Complete 5 missions without taking any Melee damage (Tech-Adept only).
Kill 1000 enemies with grenade.
Complete a mission dealing damage only by your Construct turrets on your level or higher (Tech-Adept only).
Kill 20 Elite enemies on your level or higher (Tech-Adept only).
Kill 2500 Enemies by your Kastelan Robots (Tech-Adept only).
Kill 1000 Khorne enemies.
Earn all Trophies to please the Emperor of Mankind.
Complete 25 side events during the missions.
Complete 10 Void Crusade missions.
Complete at least one mission from every type on the StarMap.
Complete 10 Investigations on the highest difficulty.
Complete an entire Priority Assignment sequence without dying.
Complete 5 Priority Assignments.
Complete a Priority Assignment on Impossible difficulty or higher.
Revive each other 50 times.
Complete 10 Cabal directives with your Cabal.
Complete a mission in local coop.
Complete 50 multiplayer missions.
Get "Unbreakable" bonus 30 times.
Get "Angel of Death" bonus 30 times.
Create 100 Warp anomalies (Psyker only).
Execute 50 enemies (only with Assassin or Crusader).
Join a Cabal.
Deal with 50 traps.
Unlock all Skill trees.
Kill 2500 Horde type enemies.
Reach maximum points in a Weekly Glory challenge.
Reach Inquisitorial Rank 50 and complete a mission in a Warzone.
Research 10 Tech tree upgrades.
Kill 50 Commander enemies.
Learn all the skills from a single Skill tree.
Kill 100 Elite creatures.
Reach Inquisitorial Rank 20 with at least one character.
Acquire 5000 Fate points.
Fuse a socket into a Relic item.
Craft 25 items.
Use Booster type Inoculator component 250 times.
Blow up 250 explosive containers.
Open 100 supply chests.
Kill 5000 enemies with melee skills.