Either Harvest or Rescue every Little Sister in the game.
Purchased every slot in all four Plasmid and Tonic tracks.
Visit Stanhamn
Complete the Private Jet laser and anti-gravity parts first
On the Helter Skelter, complete the objects that have lightbulbs before anything else
Complete the photo challenges in Oaklaville
Photograph the oakhotel from the lookout point
Fully upgrade five weapons.
Collect or Invent 53 Tonics in the Physical, Engineering and Combat tracks.
Snap a close-up photo of the skeleton
Snap a close-up photo of the sockman
Executed 100 Rejects (any mode)
You're really good with that camera!
The player has entered Sander Cohen's personal quarters.
The player has broken Fontaine's mind control.
Fully research the Rosie.
Fully research the Nitro Splicer.
Fully upgrade four weapons.
What an amazing race that was! Thrilling action all around!
The player has defeated Andrew Ryan.
Burn 300 buckets of coal in the furnace
Survive all horde stages in Night of the Hangry Horde with full kitchen health
Get 3 stars on all Night of the Hangry Horde levels with a star rating
Get 3 stars on every level in Night of the Hangry Horde World 3
Get 3 stars on every level in Night of the Hangry Horde World 2
Get 3 stars on every level in Night of the Hangry Horde World 1
Get 3 stars on every level in Carnival of Chaos World 3
Get 3 stars on all Carnival of Chaos levels
Pet a pet
Fully research the Bouncer.
Successfully invent at least 100 items.
Fully research the Houdini Splicer.
Fully upgrade three weapons.
Fully upgrade two weapons.
Fully research the Leadhead Splicer.
Successfully invented all possible ammo types.
Fully upgrade one weapon.
Purchased every slot in one of the Plasmid or Tonic tracks.
The player has taken a picture of Sander Cohen's corpse.
The player has completed Sander Cohen's great masterpiece.
Hit the jackpot at a slot machine.
Successfully complete 50 hacks.
Fully research the Spider Splicer.
Take at least one photo in every research group.
Visit Oaklaville
Photograph nana's house
Start your adventure!
The player has restored the forests of Arcadia.
Fully research the Thuggish Splicer.
Successfully invent at least one item.