Complete the main game on certain difficulties.

Unlockable	How to Unlock
Original costume	Complete the main game on Human, Devil hunter or Nephilim difficulty.
Son of Sparda costume	Complete the main game on Son of Sparda difficulty.
Super Dante perk	Complete the main game on Dante must die mode.

Complete the required mode to unlock new difficulty modes.

Difficulty	How to unlock
Dante Must Die!	Complete the game on Son of Sparda.
Heaven or Hell	Complete the game on Son of Sparda.
Hell and Hell	Complete the game on Heaven or Hell.
Son of Sparda	Complete the game on Human, Devil Hunter or Nephilim.

Art	How to unlock
Rare Art 1	Devil Trigger 666 times.
Rare Art 2	Play for 50 hours.
Rare Art 3	Deal 5,000,000 points of damage.
Rare Art 4	Complete any 60 missions with SSS rank.

You can unlock costumes by beating the game on a specific difficulty.

Unlockable	How to Unlock
Son of Sparda	Beat the game on Son of Sparda difficulty.
Standard	Beat the game on Nephilim or lower.

Complete the required mode to unlock new difficulty modes.

Difficulty	How to unlock
Dante Must Die!	Complete the game on Son of Sparda.
Heaven or Hell	Complete the game on Son of Sparda.
Hell and Hell	Complete the game on Heaven or Hell.
Son of Sparda	Complete the game on Human, Devil Hunter or Nephilim.

Art	How to unlock
Rare Art 1	Devil Trigger 666 times.
Rare Art 2	Play for 50 hours.
Rare Art 3	Total Damage of 5,000,000 points.
Rare Art 4	Complete any 60 missions with SSS rank.

Upon beating Dante Must Die mode, the Super Dante perk will be unlocked. This perk will grant the player infinite devil trigger in exchange for a 50% penalty towards the mission score.

Complete the required mode to unlock new difficulty modes.

Unlockable	How to Unlock
Heaven or Hell	Complete the game on Son of Sparda.
Hell and Hell	Complete the game on Heaven or Hell.
Son of Sparda	Complete the game on Human, Devil Hunter or Nephilim.
Vergil Must Die!	Complete the game on Son of Sparda.