The top points (50) go to the achievement 'Complete DNA Sequence 9', which we assume means the end of the game. Other than that there are quite a few points in multiplayer achievements and just for completing each of the DNA Sequences.
Here's the full list:
Mastering the Art - 30 Earn the INCOGNITO bonus (Multiplayer).
Tools of the Templar - 10 Purchase your first ABILITY in the Abstergo Store (Multiplayer).
Achiever - 10 Complete a Challenge (Multiplayer).
True Templar - 20 Reach level 20 (Multiplayer).
Looking Good - 10 Customize a PERSONA (Multiplayer).
There Is No I in Team - 20 Win a session of a team mode (Multiplayer).
Make the Headlines - 30 Obtain 12 different Accolades (Multiplayer).
The Way I Like It - 20 Edit your TEMPLAR PROFILE to change your title, emblem, and patron (Multiplayer).
Explorer - 20 Finish a session of each game mode (Multiplayer).
Tactician - 30 Score at least 2500 points in a session (Multiplayer).
The Early Years - 20 Complete Desmond Sequence 1.
Best Served Cold - 20 Complete DNA Sequence 1.
The Reluctant Assassin - 20 Complete Desmond Sequence 2.
Istanbul and Constantinople - 20 Complete DNA Sequence 2.
Escape To New York - 20 Complete Desmond Sequence 3.
Seal the Deal - 20 Complete DNA Sequence 3.
The Prince - 20 Complete DNA Sequence 4.
The Plot Thickens - 20 Complete DNA Sequence 5.
Successes and Failures - 20 Complete DNA Sequence 6.
The Rotten Apple - 20 Complete Desmond Sequence 4.
Old Boss, New Boss - 20 Complete DNA Sequence 7.
Priorities - 20 Complete DNA Sequence 8.
Are You Desmond Miles? - 20 Complete Desmond Sequence 5.
Revelations - 50 Complete DNA Sequence 9.
Fond Memories - 20 Achieve 100% Synchronization in all Sequences.
Holy Wisdom - 20 Complete the Hagia Sofia challenge level.
Capped - 20 Collect all animus data fragments.
Worth A Thousand Words - 20 Collect all of Ishak Pasha's memoir pages.
Pyromaniac - 20 Complete all Bomb Missions.
Armchair General - 20 Control all cities (except Rhodes) simultaneously in the Mediterranian Defense game.
Iron Curtain - 20 Perform a perfect den defense without using the cannon.
Spider Assassin - 20 Climb Hagia Sofia, from the ground to the pinnacle, in under 25 seconds.
A Friend Indeed - 20 Complete all Faction Creed Challenges from a single faction.
Tax Evasion - 10 Get your money back from a Templar tax collector.
The Mentor - 20 Have seven trainees reach the rank of Master Assassin.
Lightning Strikes - 20 Kill 5 guards in 5 seconds using only your hidden blades.
Overkiller - 20 Assassinate 50 guards with the hidden blade.
Show-Off - 20 Parachute onto a zipline.
Sage - 20 Collect all available books.
Fast Fingers - 20 Loot 50 dead guards with thief looting.
Mosh Pit - 20 Have 10 guards poisoned at the same time.
Mouse Trap - 20 Kill 5 guards with a scaffold after they have been stunned by caltrops.
Craft Maniac - 20 Craft 30 bombs.
My Protégé - 20 Have one trainee reach the rank of Master Assassin.
Almost Flying - 20 Parachute directly from the top of the Galata Tower to the golden horn.
Silent But Deadly - 20 Kill three guards simultaneously with only throwing knives.
I can see you - 20 Kill 5 guards while under the cover of a smoke screen bomb.
Monster's Dance - 20 Have a guard incapacitate 3 civilians while he's poisoned.