The brainchild of Shinta Nojiri, and co-developed with Rebellion Software, NeverDead stars an immortal hero called Bryce Boltzmann who, alongside his partner Arcadia, works for an agency tasked with dealing with demonic incursions. As demons from the dawn of time emerge on present-day Earth, so Bryce - armed with an arsenal of guns and a Butterfly-Blade - and the gun-toting Arcadia must locate and destroy the hostile invaders. As the malformed adversaries appear, the heavily-armed Bryce must protect his sidekick and work together to kill them all.

However, as the monsters get larger and more vicious, the side-effect of Bryce's immortality is revealed. For, as the player is attacked by the various miscreants, Bryce can be torn limb from limb, but can simply reattach the parts to his body. Even when all limbs have been removed, Bryce can roll around as a head, looking to reattach his lost parts. He can even use his amputated body parts as weapons, throwing arms into clusters of monsters, and still firing the attached gun, or lobbing his head into seemingly impossible areas, to gain access to new parts of the map.